Ser92

Site Information
VAELTsLsDEDsGkG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 452602

In vivo Characterization
Methods used to characterize site in vivo:	2D analysis ( 5 ) , [32P] ATP in vitro ( 2 ) , [32P] bio-synthetic labeling ( 5 ) , mass spectrometry ( 1 , 4 , 6 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 5 ) , phosphopeptide mapping ( 5 ) , western blotting ( 2 )
Disease tissue studied:	melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:	breast ( 2 ) , HEK293T (epithelial) ( 5 ) , HeLa (cervical) ( 6 ) , HUES-9 ('stem, embryonic') ( 4 ) , MCF10A1 (epithelial) ( 2 ) , MDCK (epithelial) ( 5 ) , WM239A (melanocyte) ( 1 )

Downstream Regulation
Effects of modification on Snail1:	activity, inhibited ( 5 ) , molecular association, regulation ( 5 ) , protein degradation ( 2 , 5 )
Effects of modification on biological processes:	carcinogenesis, inhibited ( 2 ) , transcription, altered ( 5 ) , transcription, inhibited ( 2 )
Induce interaction with:	SAP30 (human) ( 5 )

References
1	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
2	Deshiere A, et al. (2013) Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction. Oncogene 32, 1373-83 22562247 Curated Info
3	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
4	Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3 21406692 Curated Info
5	MacPherson MR, et al. (2010) Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. Mol Biol Cell 21, 244-53 19923321 Curated Info
6	Beausoleil SA, et al. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101, 12130-5 15302935 Curated Info