Ser840
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Home > Phosphorylation Site Page: > Ser840  -  CDH1 (human)

Site Information
FDYEGsGsEAAsLSs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 15754600

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoassay ( 3 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
prostate cancer ( 3 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 , 2 ) , LNCaP (prostate cell) ( 3 )

Upstream Regulation
Regulatory protein:
PBK (human) ( 1 )
Treatments:
hydroxyflutamide ( 3 ) , testosterone ( 3 ) , wortmannin ( 3 )

Downstream Regulation
Effects of modification on CDH1:
molecular association, regulation ( 2 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
carcinogenesis, altered ( 1 ) , cell motility, inhibited ( 1 )
Induce interaction with:
CTNNB1 (human) ( 2 )

References 

1

Koshino A, et al. (2021) PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer. Front Pharmacol 12, 772926
35115926   Curated Info

2

Zhao Y, et al. (2018) Nuclear E-Cadherin Acetylation Promotes Colorectal Tumorigenesis via Enhancing ¿¿-Catenin Activity. Mol Cancer Res
30401720   Curated Info

3

Górowska-Wójtowicz E, et al. (2017) Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro 40, 324-335
28163245   Curated Info

4

Inuzuka H, et al. (2012) Acetylation-dependent regulation of skp2 function. Cell 150, 179-93
22770219   Curated Info

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