Tyr876
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Home > Phosphorylation Site Page: > Tyr876  -  GluR2 (mouse)

Site Information
ykEGyNVyGIEsVKI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452173

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 4 , 6 , 7 , 8 , 9 ) , mutation of modification site ( 3 , 10 ) , phospho-antibody ( 1 , 2 , 3 , 10 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 6 ) , 'brain, hippocampus' ( 1 , 3 ) , 'neuron, cortical' ( 2 ) , 'neuron, cortical'-brain ( 3 ) , 293 (epithelial) ( 3 ) , brain ( 4 , 7 , 8 , 9 ) , HEK293T (epithelial) [GluR2 (mouse)] ( 10 ) , HEK293T (epithelial) [LYN (human)] ( 10 )

Upstream Regulation
Regulatory protein:
PDIA1 (human) ( 1 )
Putative in vivo kinases:
LYN (human) ( 10 )
Treatments:
AMPA ( 2 ) , Filipin ( 2 ) , PP2 ( 3 ) , vanadate ( 3 )

Downstream Regulation
Effects of modification on GluR2:
molecular association, regulation ( 5 , 10 )
Effects of modification on biological processes:
neural plasticity ( 3 )
Inhibit interaction with:
IQSEC1 (mouse) ( 5 )

References 

1

Lee DS, Kim TH, Park H, Kim JE (2023) PDI augments kainic acid-induced seizure activity and neuronal death by inhibiting PP2A-GluA2-PICK1-mediated AMPA receptor internalization in the mouse hippocampus. Sci Rep 13, 13927
37626185   Curated Info

2

Hayashi T (2022) Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation. Front Synaptic Neurosci 14, 921772
36387774   Curated Info

3

Yong AJH, et al. (2020) Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity. Proc Natl Acad Sci U S A 117
32071234   Curated Info

4

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

5

Scholz R, et al. (2010) AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression. Neuron 66, 768-80
20547133   Curated Info

6

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

7

Zhou J (2008) CST Curation Set: 4322; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY
Curated Info

8

Ballif BA, Carey GR, Sunyaev SR, Gygi SP (2008) Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. J Proteome Res 7, 311-8
18034455   Curated Info

9

Guo A (2007) CST Curation Set: 2675; Year: 2007; Biosample/Treatment: tissue, brain/LY; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

10

Hayashi T, Huganir RL (2004) Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases. J Neurosci 24, 6152-60
15240807   Curated Info

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