Ser257
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Home > Phosphorylation Site Page: > Ser257  -  CASP6 (human)

Site Information
TLVNRKVsQRRVDFc   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452136

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 2 )

Upstream Regulation
Kinases, in vitro:
NuaK1 (human) ( 1 , 2 , 3 )

Downstream Regulation
Effects of modification on CASP6:
enzymatic activity, inhibited ( 1 , 2 ) , molecular association, regulation ( 2 ) , protein conformation ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 )
Inhibit interaction with:
Other ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 1 ) , Huntington's disease ( 1 )

References 

1

Cao Q, et al. (2012) Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays. J Biol Chem 287, 15371-9
22433863   Curated Info

2

Velázquez-Delgado EM, Hardy JA (2012) Phosphorylation regulates assembly of the caspase-6 substrate-binding groove. Structure 20, 742-51
22483120   Curated Info

3

Suzuki A, et al. (2004) Regulation of caspase-6 and FLIP by the AMPK family member ARK5. Oncogene 23, 7067-75
15273717   Curated Info