Thr148
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Home > Phosphorylation Site Page: > Thr148  -  CRYA1 (human)

Site Information
FCGPkIQtGLDATHA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452108

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , western blotting ( 4 )
Relevant cell line - cell type - tissue:
glial ( 3 ) , neuron ( 1 ) , R28 (retinal) ( 1 , 2 ) , retinal ( 3 , 4 ) , rMC-1 ( 1 , 3 )

Downstream Regulation
Effects of modification on CRYA1:
activity, induced ( 1 ) , intracellular localization ( 2 ) , molecular association, regulation ( 1 ) , phosphorylation ( 3 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 , 4 ) , transcription, inhibited ( 3 )
Inhibit interaction with:
CRYA1 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
diabetes mellitus ( 4 )

References 

1

Nath M, et al. (2022) Evidence for Paracrine Protective Role of Exogenous αA-Crystallin in Retinal Ganglion Cells. eNeuro
35168949   Curated Info

2

Nath M, Fort PE (2022) αA-Crystallin Mediated Neuroprotection in the Retinal Neurons Is Independent of Protein Kinase B. Front Neurosci 16, 912757
35669493   Curated Info

3

Nath M, Shan Y, Myers AM, Fort PE (2021) HspB4/αA-Crystallin Modulates Neuroinflammation in the Retina via the Stress-Specific Inflammatory Pathways. J Clin Med 10
34071438   Curated Info

4

Ruebsam A, et al. (2018) A specific phosphorylation regulates the protective role of αA-crystallin in diabetes. JCI Insight 3
29467334   Curated Info

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