Tyr1320
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Home > Phosphorylation Site Page: > Tyr1320  -  PTPRJ (human)

Site Information
NtTAMtIyENLAPVT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 15228667

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , mutation of modification site ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Fyn (human) ( 2 ) , Src (human) ( 2 )
Kinases, in vitro:
Src (human) ( 2 )
Treatments:
VEGF ( 2 )

Downstream Regulation
Effects of modification on PTPRJ:
enzymatic activity, induced ( 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell motility, induced ( 2 )
Induce interaction with:
Src (human) ( 2 )

References 

1

Spring K, et al. (2014) Phosphorylation of DEP-1/PTPRJ on threonine 1318 regulates Src activation and endothelial cell permeability induced by vascular endothelial growth factor. Cell Signal 26, 1283-93
24583284   Curated Info

2

Spring K, et al. (2012) Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation. Blood 120, 2745-56
22898603   Curated Info

3

Moritz A (2010) CST Curation Set: 9059; Year: 2010; Biosample/Treatment: cell line, HeLa/Peroxide; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info