Ser338
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Home > Phosphorylation Site Page: > Ser338  -  AT1 (rat)

Site Information
stKMstLsYRPSDNM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452092

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 1 , 3 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
angiotensin ( 3 ) , GF109203X ( 3 ) , phorbol_ester ( 3 )

Downstream Regulation
Effects of modification on AT1:
activity, induced ( 2 ) , molecular association, regulation ( 1 )
Induce interaction with:
ARRB2 (rat) ( 1 )

References 

1

Tóth AD, et al. (2018) Heterologous phosphorylation-induced formation of a stability lock permits regulation of inactive receptors by β-arrestins. J Biol Chem 293, 876-892
29146594   Curated Info

2

Policha A, et al. (2006) Role of angiotensin II type 1A receptor phosphorylation, phospholipase D, and extracellular calcium in isoform-specific protein kinase C membrane translocation responses. J Biol Chem 281, 26340-9
16831865   Curated Info

3

Qian H, Pipolo L, Thomas WG (1999) Identification of protein kinase C phosphorylation sites in the angiotensin II (AT1A) receptor. Biochem J 343 Pt 3, 637-44
10527943   Curated Info