Ser467
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Home > Phosphorylation Site Page: > Ser467  -  PFKFB2 (cow)

Site Information
PVRMRRNsFTPLSSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448460

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , peptide sequencing ( 3 ) , phosphoamino acid analysis ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
Akt1 (human) ( 1 , 2 , 3 , 4 ) , p70S6K (rat) ( 4 ) , PKACA (cow) ( 4 , 5 ) , RSK2 (human) ( 4 )
Treatments:
insulin ( 3 ) , wortmannin ( 3 )

Downstream Regulation
Effects of modification on PFKFB2:
enzymatic activity, induced ( 4 ) , molecular association, regulation ( 5 )
Induce interaction with:
Other ( 5 )

References 

1

Mouton V, et al. (2007) Evaluation of the role of protein kinase Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation. Cell Signal 19, 52-61
16829026   Curated Info

2

Deprez J, et al. (2000) Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase. Biochem J 347 Pt 1, 305-12
10727432   Curated Info

3

Bertrand L, et al. (1999) Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B. J Biol Chem 274, 30927-33
10521487   Curated Info

4

Deprez J, et al. (1997) Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. J Biol Chem 272, 17269-75
9211863   Curated Info

5

Kitamura K, Kangawa K, Matsuo H, Uyeda K (1988) Phosphorylation of myocardial fructose-6-phosphate,2-kinase: fructose-2,6-bisphosphatase by cAMP-dependent protein kinase and protein kinase C. Activation by phosphorylation and amino acid sequences of the phosphorylation sites. J Biol Chem 263, 16796-801
2846551   Curated Info