Tyr1020
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Home > Phosphorylation Site Page: > Tyr1020  -  PDGFRB (mouse)

Site Information
PNESDNDyIIPLPDP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447523

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 , 4 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:
'muscle, smooth'-thoracic aorta ( 2 ) , 293 (epithelial) ( 2 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 4 ) , MEF (fibroblast) ( 3 ) , PAE (endothelial) ( 3 )

Upstream Regulation
Regulatory protein:
GRK5 (mouse) ( 2 )
Putative upstream phosphatases:
PTPN2 (mouse) ( 3 )
Phosphatases, in vitro:
PTPN2 (mouse) ( 3 )
Treatments:
PDGF ( 2 , 3 )

Downstream Regulation
Effects of modification on PDGFRB:
phosphorylation ( 4 )

References 

1

Yang W, Wetterskog D, Matsumoto Y, Funa K (2008) Kinetics of repression by modified p53 on the PDGF beta-receptor promoter. Int J Cancer 123, 2020-30
18697203   Curated Info

2

Wu JH, et al. (2006) Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. J Biol Chem 281, 37758-72
17018529   Curated Info

3

Persson C, et al. (2004) Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol 24, 2190-201
14966296   Curated Info

4

Saito Y, et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem 277, 23216-22
11940581   Curated Info