Ser192
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Home > Phosphorylation Site Page: > Ser192  -  GATA2 (human)

Site Information
PsTTGAAsPASSSAG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14573920

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 2 , 3 , 4 , 5 , 6 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 3 )
Disease tissue studied:
HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , leukemia ( 6 ) , acute myelogenous leukemia ( 1 , 6 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , breast ( 2 ) , G1E (erythroid) ( 3 ) , HeLa (cervical) ( 4 , 5 ) , K562 (erythroid) ( 5 ) , Kasumi-1 (myeloid) ( 1 ) , KG-1 (myeloid) ( 6 )

Upstream Regulation
Putative in vivo kinases:
P38A (human) ( 3 )
Treatments:
mutation ( 3 ) , okadaic_acid ( 1 ) , SB203580 ( 3 ) , siRNA ( 3 )

Downstream Regulation
Effects of modification on GATA2:
intracellular localization ( 3 ) , molecular association, regulation ( 3 ) , phosphorylation ( 1 , 3 )
Effects of modification on biological processes:
carcinogenesis, induced ( 3 ) , transcription, induced ( 3 )
Induce interaction with:
DNA ( 3 )

References 

1

Katsumura KR, et al. (2016) GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells. Cell Rep 16, 2428-41
27545880   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Katsumura KR, et al. (2014) Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2. EMBO Rep 15, 938-47
25056917   Curated Info

4

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

5

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

6

Weber C, Schreiber TB, Daub H (2012) Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics 75, 1343-56
22115753   Curated Info

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