Ser3
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Home > Phosphorylation Site Page: > Ser3  -  DAP (human)

Site Information
_____MssPPEGkLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 14572132

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 8 ) , immunoprecipitation ( 8 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 8 , 9 ) , mutation of modification site ( 8 )
Disease tissue studied:
breast cancer ( 4 ) , breast ductal carcinoma ( 4 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 , 4 ) , ovarian cancer ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
amino_acid_starvation ( 8 ) , EGF ( 1 ) , rapamycin ( 8 ) , refeeding ( 8 ) , Torin1 ( 8 )

Downstream Regulation
Effects of modification on DAP:
activity, inhibited ( 8 )
Effects of modification on biological processes:
autophagy, altered ( 8 )

References 

1

Huang H, et al. (2016) Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography. Mol Cell Proteomics 15, 3282-3296
27281782   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

6

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

7

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

8

Koren I, Reem E, Kimchi A (2010) DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr Biol 20, 1093-8
20537536   Curated Info

9

Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501
19413330   Curated Info

10

Zougman A, Wiƛniewski JR (2006) Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins. J Proteome Res 5, 925-34
16602700   Curated Info