Ser315
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Home > Phosphorylation Site Page: > Ser315  -  IkB-beta (human)

Site Information
sGPCSsSsDSDSGDE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452014

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 , 3 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 ) , phosphoamino acid analysis ( 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
A293T ('renal, embryonic') ( 2 ) , C2C12 (myoblast) ( 1 ) , Jurkat (T lymphocyte) ( 3 )

Upstream Regulation
Kinases, in vitro:
CK2A1 (human) ( 3 )

Downstream Regulation
Effects of modification on IkB-beta:
activity, induced ( 1 , 3 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
transcription, altered ( 1 ) , transcription, inhibited ( 2 )
Induce interaction with:
CCDC32 (mouse) ( 1 )

References 

1

Biswas G, Anandatheerthavarada HK, Zaidi M, Avadhani NG (2003) Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J Cell Biol 161, 507-19
12732617   Curated Info

2

McKinsey TA, Chu ZL, Ballard DW (1997) Phosphorylation of the PEST domain of IkappaBbeta regulates the function of NF-kappaB/IkappaBbeta complexes. J Biol Chem 272, 22377-80
9278383   Curated Info

3

Chu ZL, et al. (1996) Basal phosphorylation of the PEST domain in the I(kappa)B(beta) regulates its functional interaction with the c-rel proto-oncogene product. Mol Cell Biol 16, 5974-84
8887627   Curated Info