Ser409
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Home > Phosphorylation Site Page: > Ser409  -  GABRB1 (mouse)

Site Information
IQyRKPLssREGFGR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451812

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 1 ) , [32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 1 , 3 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 1 , 3 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 3 ) , neuron-brain ( 3 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 , 3 )
Kinases, in vitro:
CAMK2A (rat) ( 2 )
Treatments:
cAMP_analog ( 1 ) , colforsin ( 1 ) , NKH_477 ( 3 )

Downstream Regulation
Effects of modification on GABRB1:
activity, induced ( 1 ) , receptor desensitization, altered ( 3 )

References 

1

McDonald BJ, et al. (1998) Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinase. Nat Neurosci 1, 23-8
10195104   Curated Info

2

McDonald BJ, Moss SJ (1994) Differential phosphorylation of intracellular domains of gamma-aminobutyric acid type A receptor subunits by calcium/calmodulin type 2-dependent protein kinase and cGMP-dependent protein kinase. J Biol Chem 269, 18111-7
8027073   Curated Info

3

Moss SJ, Smart TG, Blackstone CD, Huganir RL (1992) Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation. Science 257, 661-5
1323140   Curated Info