Ser77

Site Information
PTAGALYsGsEGDsE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 451802

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 ) , peptide sequencing ( 3 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 3 )
Relevant cell line - cell type - tissue:	ES (stem) ( 1 ) , HeLa (cervical) ( 2 , 3 )

Upstream Regulation
Kinases, in vitro:	CK2A1 (human) ( 4 )

References
1	Blaker AL, Taylor JM, Mack CP (2009) PKA-dependent phosphorylation of serum response factor inhibits smooth muscle-specific gene expression. Arterioscler Thromb Vasc Biol 29, 2153-60 19778940 Curated Info
2	Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7 18669648 Curated Info
3	Janknecht R, et al. (1992) Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. EMBO J 11, 1045-54 1547771 Curated Info
4	Manak JR, Prywes R (1991) Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II. Mol Cell Biol 11, 3652-9 2046671 Curated Info