Ser112

Site Information
GsGPVHIsGQHLVAV SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 13830094

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 )
Disease tissue studied:	acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 3 ) , acute megakaryoblastic leukemia (M7) ( 3 ) , acute monoblastic leukemia (M5a) or acute monocytic leukemia (M5b) ( 3 ) , acute myeloblastic leukemia, with granulocytic maturation (M2) ( 3 ) , acute myeloblastic leukemia, without maturation (M1) ( 3 ) , lung cancer ( 2 , 4 , 7 ) , non-small cell lung cancer ( 4 , 7 ) , non-small cell lung adenocarcinoma ( 2 , 4 ) , B cell lymphoma ( 3 ) , non-Hodgkin's lymphoma ( 3 ) , multiple myeloma ( 3 )
Relevant cell line - cell type - tissue:	AML-193 (monocyte) ( 3 ) , CMK (megakaryoblast) ( 3 ) , CTS (myeloid) ( 3 ) , DOHH2 ('B lymphocyte, precursor') ( 3 ) , HCC78 (pulmonary) ( 4 ) , HCT116 (intestinal) ( 6 ) , HEL (erythroid) ( 3 ) , HeLa (cervical) ( 1 , 5 ) , Kasumi-1 (myeloid) ( 3 ) , KG-1 (myeloid) ( 3 ) , lung ( 7 ) , MV4-11 (macrophage) ( 3 ) , OPM-2 (plasma cell) ( 3 ) , P31/FUJ (erythroid) ( 3 ) , PC9 (pulmonary) ( 2 ) , RL ('B lymphocyte, precursor') ( 3 ) , RPMI-8266 (plasma cell) ( 3 ) , SU-DHL-6 (B lymphocyte) ( 3 ) , U266 (plasma cell) ( 3 )

References
1	Huang H, et al. (2016) Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography. Mol Cell Proteomics 15, 3282-3296 27281782 Curated Info
2	Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622 25814448 Curated Info
3	Casado P, et al. (2013) Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors. Genome Biol 14, R37 23628362 Curated Info
4	Possemato A (2011) CST Curation Set: 11921; Year: 2011; Biosample/Treatment: cell line, HCC78/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
6	Nagano K, et al. (2009) Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment. Proteomics 9, 2861-74 19415658 Curated Info
7	Michaud C (2007) CST Curation Set: 2300; Year: 2007; Biosample/Treatment: tissue, lung/-; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info