Ser83
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser83  -  LATS2 (human)

Site Information
ALREIRysLLPFANE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451703

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 3 , 4 ) , microscopy-colocalization with upstream kinase ( 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 1 , 2 , 4 )
Kinases, in vitro:
AurA (human) ( 4 )
Treatments:
AZD1152 ( 2 ) , MLN8054 ( 2 ) , nocodazole ( 4 ) , VX-680 ( 2 )

Downstream Regulation
Effects of modification on LATS2:
intracellular localization ( 4 )
Effects of modification on biological processes:
cell cycle regulation ( 2 )

References 

1

Zhang L, et al. (2012) KIBRA Regulates Aurora Kinase Activity and Is Required for Precise Chromosome Alignment During Mitosis. J Biol Chem 287, 34069-77
22904328   Curated Info

2

Emery A, et al. (2011) A novel cell-based, high-content assay for phosphorylation of lats2 by aurora a. J Biomol Screen 16, 925-31
21788394   Curated Info

3

Yabuta N, et al. (2011) The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. Cell Cycle 10, 2724-36
21822051   Curated Info

4

Toji S, et al. (2004) The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells 9, 383-97
15147269   Curated Info