Ser67

Site Information
VAsPAAPsPGssGGG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 451573

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 3 , 4 , 6 , 7 , 8 , 9 , 11 , 12 ) , phospho-antibody ( 5 , 10 ) , western blotting ( 5 , 10 )
Disease tissue studied:	neuroblastoma ( 6 )
Relevant cell line - cell type - tissue:	'brain, amygdala' ( 5 ) , 'brain, cerebral cortex' ( 9 , 12 ) , 'brain, hippocampus' ( 5 , 10 ) , 'brain, striatum' ( 5 ) , brain ( 8 , 11 ) , heart ( 4 ) , kidney ( 7 ) , N1E-115 (neuron) ( 6 ) , neuron:postsynaptic density-'brain, hippocampus, CA1 region' ( 3 )

Upstream Regulation
Regulatory protein:	ARPP-21 (mouse) ( 5 )
Treatments:	9d ( 10 ) , LPA ( 6 )

References
1	Mao LM, Thallapureddy K, Wang JQ (2023) Effects of propofol on presynaptic synapsin phosphorylation in the mouse brain in vivo. Brain Res 1823, 148671 37952872 Curated Info
2	Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250 27841257 Curated Info
3	Li J, et al. (2016) Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Sci Signal 9, rs8 27507650 Curated Info
4	Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11 23737553 Curated Info
5	Davis MM, et al. (2012) Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits. Eur J Neurosci 35, 300-8 22250817 Curated Info
6	Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201 21454597 Curated Info
7	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
8	Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9 20415495 Curated Info
9	Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82 19737024 Curated Info
10	Tallent MK, et al. (2009) In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem 284, 174-81 19004831 Curated Info
11	Zhou J (2008) CST Curation Set: 4338; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pSP Curated Info
12	Munton RP, et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics 6, 283-93 17114649 Curated Info