Ser310
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Home > Phosphorylation Site Page: > Ser310  -  LTB4R (human)

Site Information
KLLEGtGsEAsstRR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 13310168

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 3 , 5 ) , mutation of modification site ( 1 , 2 , 4 ) , western blotting ( 2 )
Disease tissue studied:
leukemia ( 1 , 2 ) , lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 )
Relevant cell line - cell type - tissue:
BaF3 ('B lymphocyte, precursor') ( 2 ) , CHO (fibroblast) ( 4 ) , CHO-K1 (fibroblast) ( 2 ) , HeLa (cervical) ( 2 ) , HL60 (myeloid) ( 1 , 2 ) , leukocyte-blood ( 5 ) , lung ( 3 ) , RBL-2H3 (basophil) ( 2 )

Upstream Regulation
Treatments:
Ca(2+) ( 2 ) , LTB4 ( 2 )

Downstream Regulation
Effects of modification on LTB4R:
receptor desensitization, induced ( 1 ) , receptor internalization, induced ( 4 )
Effects of modification on biological processes:
cell motility, altered ( 1 ) , cell motility, induced ( 2 ) , endocytosis, inhibited ( 1 ) , signaling pathway regulation ( 2 )

References 

1

Lundgren SM, et al. (2023) Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors. Sci Signal 16, eadd1845
37788324   Curated Info

2

Nakanishi Y, et al. (2018) Stepwise phosphorylation of leukotriene B receptor 1 defines cellular responses to leukotriene B. Sci Signal 11
30131369   Curated Info

3

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

4

Aratake Y, et al. (2012) Helix 8 of leukotriene B4 receptor 1 inhibits ligand-induced internalization. FASEB J 26, 4068-78
22707565   Curated Info

5

Raijmakers R, et al. (2010) Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer. Anal Chem 82, 824-32
20058876   Curated Info

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