Ser459

Site Information
VWGVGRDsGSNRDFA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 13309858

In vivo Characterization
Methods used to characterize site in vivo:	immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	'neuron, cortical'-brain ( 1 ) , retina ( 1 )

Downstream Regulation
Effects of modification on Fe65:	molecular association, regulation ( 1 )
Effects of modification on biological processes:	cell growth, induced ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:	ARF6 (human) ( 1 )

References
1	Chau DD, et al. (2022) Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling. FASEB J 36, e22594 36250347 Curated Info