Thr291
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Home > Phosphorylation Site Page: > Thr291  -  IkB-alpha (human)

Site Information
EDEEsyDtEsEFTEF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451526

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 2 , 3 ) , phosphopeptide mapping ( 4 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 4 )
Kinases, in vitro:
CK2A1 (human) ( 1 , 3 , 4 )

Downstream Regulation
Effects of modification on IkB-alpha:
protein degradation ( 3 )

References 

1

Shen J, Channavajhala P, Seldin DC, Sonenshein GE (2001) Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. J Immunol 167, 4919-25
11673497   Curated Info

2

Bren GD, Pennington KN, Paya CV (2000) PKC-zeta-associated CK2 participates in the turnover of free IkappaBalpha. J Mol Biol 297, 1245-58
10764587   Curated Info

3

Lin R, et al. (1996) Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Mol Cell Biol 16, 1401-9
8657113   Curated Info

4

McElhinny JA, et al. (1996) Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation. Mol Cell Biol 16, 899-906
8622692   Curated Info