Ser293
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Home > Phosphorylation Site Page: > Ser293  -  IkB-alpha (human)

Site Information
EEsyDtEsEFTEFtE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451525

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 ) , phosphopeptide mapping ( 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 1 , 2 )
Kinases, in vitro:
CK2A1 (human) ( 1 , 2 )

Downstream Regulation
Effects of modification on IkB-alpha:
protein degradation ( 1 )

References 

1

Bren GD, Pennington KN, Paya CV (2000) PKC-zeta-associated CK2 participates in the turnover of free IkappaBalpha. J Mol Biol 297, 1245-58
10764587   Curated Info

2

McElhinny JA, et al. (1996) Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation. Mol Cell Biol 16, 899-906
8622692   Curated Info