Ser298
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Home > Phosphorylation Site Page: > Ser298  -  HDAC4 (human)

Site Information
ACSSAPGsGPSsPNN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1322400

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 1 )
Kinases, in vitro:
GSK3B (human) ( 1 )

Downstream Regulation
Effects of modification on HDAC4:
intracellular localization ( 1 , 2 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
cell motility, altered ( 1 )

References 

1

Cernotta N, Clocchiatti A, Florean C, Brancolini C (2011) Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility. Mol Biol Cell 22, 278-89
21118993   Curated Info

2

Paroni G, et al. (2008) PP2A Regulates HDAC4 Nuclear Import. Mol Biol Cell 19, 655-67
18045992   Curated Info