Ser49
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Home > Phosphorylation Site Page: > Ser49  -  MAFA (mouse)

Site Information
CHRLPPGsLSStPLS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1320400

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:
beta-pancreas ( 1 ) , HeLa (cervical) ( 3 ) , MIN6 (pancreatic) ( 1 )

Downstream Regulation
Effects of modification on MAFA:
molecular association, regulation ( 3 )
Induce interaction with:
MAFA (mouse) ( 3 )

References 

1

Iwaoka R, Kataoka K (2018) Glucose regulates MafA transcription factor abundance and insulin gene expression by inhibiting AMP-activated protein kinase in pancreatic β-cells. J Biol Chem
29348175   Curated Info

2

Kanai K, et al. (2011) Proteasome activator PA28{gamma} stimulates degradation of GSK3-phosphorylated insulin transcription activator MAFA. J Mol Endocrinol 47, 119-27
21646385   Curated Info

3

Guo S, Vanderford NL, Stein R (2010) Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding. J Biol Chem 285, 12655-61
20208071   Curated Info