Tyr1242

Site Information
KAFDNPDyWNHSLPP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 451502

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 )
Disease tissue studied:	gastric cancer ( 4 ) , neuroblastoma ( 1 , 2 )
Relevant cell line - cell type - tissue:	AZ-521 (gastric) ( 4 ) , HEK293T (epithelial) ( 3 ) , SK-N-BE(2) (neural crest) ( 1 , 2 )

Downstream Regulation
Effects of modification on HER4:	molecular association, regulation ( 3 , 5 , 6 )
Induce interaction with:	Arg (human) ( 3 ) , GRB2 (human) ( 5 ) , SHC1 (human) ( 3 , 5 , 6 )

References
1	Palacios-Moreno J, et al. (2015) Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts. PLoS Comput Biol 11, e1004130 25884760 Curated Info
2	Guo A (2010) CST Curation Set: 10549; Year: 2010; Biosample/Treatment: cell line, SKNBE(2)/NGF; Disease: neuroblastoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	Kaushansky A, et al. (2008) System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol 15, 808-17 18721752 Curated Info
4	Ren H (2008) CST Curation Set: 3915; Year: 2008; Biosample/Treatment: cell line, AZ-521/untreated; Disease: gastric cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	Schulze WX, Deng L, Mann M (2005) Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol 1, 2005.0008 16729043 Curated Info
6	Cohen BD, Green JM, Foy L, Fell HP (1996) HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers. J Biol Chem 271, 4813-8 8617750 Curated Info