Tyr1056
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Home > Phosphorylation Site Page: > Tyr1056  -  HER4 (human)

Site Information
GHsPPPAyTPMSGNQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451500
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 )
Disease tissue studied:
breast cancer ( 2 ) , prostate cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
HER4 (human) ( 3 )

Downstream Regulation
Effects of modification on HER4:
activity, induced ( 3 ) , molecular association, regulation ( 1 , 4 , 5 )
Effects of modification on biological processes:
cell growth, altered ( 3 )
Induce interaction with:
Arg (human) ( 1 ) , CBL (human) ( 1 ) , PIK3C2A (human) ( 5 ) , PIK3R1 (human) ( 1 ) , PIK3R2 (human) ( 1 , 4 ) , PIK3R3 (human) ( 1 )

References 

1

Kaushansky A, et al. (2008) System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol 15, 808-17
18721752   Curated Info

2

Michaud C (2006) CST Curation Set: 1989; Year: 2006; Biosample/Treatment: cell line, CAL-51/serum starved; Disease: breast cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Gallo RM, et al. (2006) Phosphorylation of ErbB4 on Tyr1056 is critical for inhibition of colony formation by prostate tumor cell lines. Biochem Biophys Res Commun 349, 372-82
16934755   Curated Info

4

Schulze WX, Deng L, Mann M (2005) Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol 1, 2005.0008
16729043   Curated Info

5

Cohen BD, Green JM, Foy L, Fell HP (1996) HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers. J Biol Chem 271, 4813-8
8617750   Curated Info