Thr288
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Home > Phosphorylation Site Page: > Thr288  -  CCND1 (human)

Site Information
VDLACtPtDVRDVDI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451435

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 3 )
Disease tissue studied:
bone cancer ( 3 ) , breast cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
DYRK1B (human) ( 1 )
Putative in vivo kinases:
DYRK1B (human) ( 1 )
Treatments:
DIF-3 ( 1 ) , lithium ( 1 )

Downstream Regulation
Effects of modification on CCND1:
intracellular localization ( 1 ) , protein degradation ( 1 , 3 )

References 

1

Takahashi-Yanaga F, et al. (2006) Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells. J Biol Chem 281, 38489-97
17046823   Curated Info

2

Alao JP, et al. (2006) Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. Mol Cancer 5, 8
16504004   Curated Info

3

Germain D, Russell A, Thompson A, Hendley J (2000) Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286. J Biol Chem 275, 12074-9
10766840   Curated Info