Thr288
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Home > Phosphorylation Site Page: > Thr288  -  CCND1 (mouse)

Site Information
AGLACtPtDVRDVDI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451435

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , flow cytometry ( 1 ) , mutation of modification site ( 1 , 2 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
DYRK1B (mouse) ( 2 )
Kinases, in vitro:
DYRK1B (mouse) ( 2 ) , GSK3B (mouse) ( 2 )
Treatments:
lithium ( 2 )

Downstream Regulation
Effects of modification on CCND1:
protein degradation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

Jin K, et al. (2009) Mirk regulates the exit of colon cancer cells from quiescence. J Biol Chem 284, 22916-25
19542220   Curated Info

2

Zou Y, et al. (2004) Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288. J Biol Chem 279, 27790-8
15075324   Curated Info