Ser205
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Home > Phosphorylation Site Page: > Ser205  -  NFkB-p65 (human)

Site Information
RVNRNSGsCLGGDEI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1295501

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 )
Relevant cell line - cell type - tissue:
BAEC (endothelial) ( 2 ) , MEF (fibroblast) ( 3 )

Downstream Regulation
Effects of modification on NFkB-p65:
intracellular localization ( 3 )
Effects of modification on biological processes:
transcription, altered ( 3 , 4 ) , transcription, induced ( 1 , 2 )

References 

1

Hochrainer K, Racchumi G, Anrather J (2013) Site-specific phosphorylation of the p65 protein subunit mediates selective gene expression by differential NF-κB and RNA polymerase II promoter recruitment. J Biol Chem 288, 285-93
23100252   Curated Info

2

Seldon MP, et al. (2007) Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276. J Immunol 179, 7840-51
18025230   Curated Info

3

Hochrainer K, Racchumi G, Anrather J (2007) Hypo-phosphorylation leads to nuclear retention of NF-kappaB p65 due to impaired IkappaBalpha gene synthesis. FEBS Lett 581, 5493-9
17991436   Curated Info

4

Anrather J, Racchumi G, Iadecola C (2005) cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B. J Biol Chem 280, 244-52
15516339   Curated Info