Ser371
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Home > Phosphorylation Site Page: > Ser371  -  p53 (human)

Site Information
AHsSHLkskkGQsts   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447533

In vivo Characterization
Methods used to characterize site in vivo:
modification-specific antibody ( 2 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 3 ) , Aspc1 (pancreatic) ( 1 ) , COLO-320 (intestinal) ( 1 ) , NCI-H596 (pulmonary) ( 1 ) , NHF (fibroblast) ( 2 ) , OM431 ( 1 ) , SJSA-1 (bone cell) ( 1 ) , SW680 (intestinal) ( 1 ) , WM4 ( 1 ) , WM5 ( 1 ) , WM793 ( 1 )

Upstream Regulation
Kinases, in vitro:
CDK7 (human) ( 4 ) , PKCA (human) ( 3 )
Treatments:
UV ( 1 , 2 )

Downstream Regulation
Effects of modification on p53:
activity, induced ( 3 , 4 ) , molecular association, regulation ( 4 )
Induce interaction with:
DNA ( 4 )

References 

1

Minamoto T, et al. (2001) Distinct pattern of p53 phosphorylation in human tumors. Oncogene 20, 3341-7
11423984   Curated Info

2

Buschmann T, et al. (2000) p53 phosphorylation and association with murine double minute 2, c-Jun NH2-terminal kinase, p14ARF, and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation. Cancer Res 60, 896-900
10706102   Curated Info

3

Youmell M, Park SJ, Basu S, Price BD (1998) Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta. Biochem Biophys Res Commun 245, 514-8
9571186   Curated Info

4

Lu H, Fisher RP, Bailey P, Levine AJ (1997) The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro. Mol Cell Biol 17, 5923-34
9315650   Curated Info