Ser167

Site Information
LRHIKLHsGEKPFKC SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 451355

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mass spectrometry (in vitro) ( 2 ) , microscopy-colocalization with upstream kinase ( 2 ) , mutation of modification site ( 2 , 3 ) , phosphopeptide mapping ( 3 ) , western blotting ( 2 )
Disease tissue studied:	lymphoma ( 2 ) , Burkitt's lymphoma ( 2 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 2 ) , HEK293T (epithelial) ( 3 ) , Raji (B lymphocyte) ( 2 ) , RAW 264.7 (macrophage) ( 1 ) , VL3-3M2 (T lymphocyte) ( 3 )

Downstream Regulation
Effects of modification on Ikaros:	intracellular localization ( 3 )

References
1	Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44 25367039 Curated Info
2	Ma H, et al. (2013) Regulatory Phosphorylation of Ikaros by Bruton's Tyrosine Kinase. PLoS One 8, e71302 23977012 Curated Info
3	Dovat S, et al. (2002) A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains. Genes Dev 16, 2985-90 12464629 Curated Info