Ser249
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Home > Phosphorylation Site Page: > Ser249  -  HNF1A (human)

Site Information
IQRGVsPsQAQGLGS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451310

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 )
Relevant cell line - cell type - tissue:
heart ( 1 ) , HeLa (cervical) ( 1 ) , HepG2 (hepatic) ( 1 ) , intestine ( 1 ) , kidney ( 1 ) , liver ( 1 , 2 ) , lung ( 1 ) , muscle ( 1 ) , pancreas ( 1 ) , RINm5F ( 1 ) , spleen ( 1 ) , testis ( 1 )

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 1 )
Kinases, in vitro:
ATM (human) ( 1 ) , DYRK1B (human) ( 3 )
Treatments:
ionizing_radiation ( 1 ) , KU-55933 ( 1 )

Downstream Regulation
Effects of modification on HNF1A:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Zhao L, et al. (2014) Serine 249 phosphorylation by ATM protein kinase regulates hepatocyte nuclear factor-1α transactivation. Biochim Biophys Acta 1839, 604-20
24821553   Curated Info

2

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

3

Lim S, Jin K, Friedman E (2002) Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. J Biol Chem 277, 25040-6
11980910   Curated Info