Tyr499
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Home > Phosphorylation Site Page: > Tyr499  -  Kv1.3 (human)

Site Information
EGEEQSQyMHVGsCQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451294

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 3 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
GRB10 (human) ( 2 )
Putative in vivo kinases:
Src (human) ( 3 ) , TrkB (human) ( 2 )
Treatments:
BDNF ( 2 ) , depolarization ( 1 )

Downstream Regulation
Effects of modification on Kv1.3:
activity, induced ( 3 ) , activity, inhibited ( 2 )
Effects of modification on biological processes:
cell growth, induced ( 1 )

References 

1

Jiménez-Pérez L, et al. (2016) Molecular Determinants of Kv1.3 Potassium Channels-induced Proliferation. J Biol Chem 291, 3569-80
26655221   Curated Info

2

Colley BS, et al. (2009) Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc. BMC Neurosci 10, 8
19166614   Curated Info

3

Cook KK, Fadool DA (2002) Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase. J Biol Chem 277, 13268-80
11812778   Curated Info