Ser91
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Home > Phosphorylation Site Page: > Ser91  -  CDK5R1 (human)

Site Information
ENLKKSLsCANLSTF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12607404

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 1 ) , pancreatic cancer ( 2 ) , pancreatic carcinoma ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HEK293T (epithelial) ( 2 ) , MIN6 (pancreatic) ( 2 ) , Neuro-2a (neuron) ( 1 )

Upstream Regulation
Putative in vivo kinases:
QIK (human) ( 2 )
Kinases, in vitro:
QIK (human) ( 2 )

Downstream Regulation
Effects of modification on CDK5R1:
molecular association, regulation ( 2 ) , protein degradation ( 2 ) , ubiquitination ( 2 )
Induce interaction with:
PJA2 (human) ( 2 )

References 

1

Takasugi T, et al. (2016) Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination. J Biol Chem 291, 4649-57
26631721   Curated Info

2

Sakamaki J, et al. (2014) Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation. Nat Cell Biol 16, 234-44
24561619   Curated Info

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