Ser696
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Home > Phosphorylation Site Page: > Ser696  -  Ret (human)

Site Information
SSGARRPsLDsMENQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451267

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 6 ) , mass spectrometry ( 1 , 2 , 3 , 5 ) , mutation of modification site ( 4 , 6 ) , phospho-antibody ( 6 )
Disease tissue studied:
adrenal cancer ( 4 ) , pheochromocytoma ( 4 ) , breast cancer ( 2 ) , breast ductal carcinoma ( 2 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
'neuron, sympathetic' ( 4 ) , breast ( 1 , 2 ) , COS (fibroblast) ( 4 ) , HCT116 (intestinal) ( 5 ) , MV4-11 (macrophage) ( 5 ) , PC-12 (chromaffin) ( 4 ) , SH-SY5Y (neural crest) ( 3 , 6 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 4 , 6 )
Kinases, in vitro:
PKACA (human) ( 6 )
Treatments:
cAMP_analog ( 6 ) , colforsin ( 4 , 6 ) , GDNF ( 6 ) , KT5720 ( 6 ) , LRRK2-IN-1 ( 3 )

Downstream Regulation
Effects of modification on Ret:
enzymatic activity, induced ( 6 ) , molecular association, regulation ( 4 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 6 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Luerman GC, et al. (2014) Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. J Neurochem 128, 561-76
24117733   Curated Info

4

Perrinjaquet M, Vilar M, Ibáñez CF (2010) Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase. J Biol Chem 285, 31867-75
20682772   Curated Info

5

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

6

Fukuda T, Kiuchi K, Takahashi M (2002) Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase. J Biol Chem 277, 19114-21
11886862   Curated Info