Ser14
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Home > Phosphorylation Site Page: > Ser14  -  STX1A (rat)

Site Information
ELRTAKDsDDDDDVt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451261

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , phospho-antibody ( 1 , 4 , 6 ) , western blotting ( 1 , 4 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 3 ) , 'brain, cerebellum' ( 3 ) , 'brain, cerebral cortex' ( 3 ) , 'cilia, olfactory epithelium' ( 6 ) , 'neuron, cerebellar granule'-brain ( 6 ) , 'neuron, cortical'-brain ( 6 ) , 'neuron, hippocampal'-brain ( 6 ) , adrenal medulla ( 6 ) , brain ( 2 , 4 ) , neuron-'brain, hippocampus' ( 1 ) , neuron-spinal cord ( 6 ) , stomach ( 3 )

Upstream Regulation
Regulatory protein:
CK1A (rat) ( 1 )
Putative in vivo kinases:
CK2A1 (rat) ( 1 , 4 )
Kinases, in vitro:
CK2A1 (human) ( 6 ) , CK2A1 (rat) ( 5 )
Treatments:
cocaine ( 2 ) , DMAT ( 4 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on STX1A:
molecular association, regulation ( 6 )
Effects of modification on biological processes:
endocytosis, inhibited ( 1 ) , exocytosis, altered ( 4 ) , signaling pathway regulation ( 2 )
Induce interaction with:
SNAP-25 (rat) ( 6 )

References 

1

Shi VH, et al. (2020) Phosphorylation of Syntaxin-1a by casein kinase 2α regulates pre-synaptic vesicle exocytosis from the reserve pool. J Neurochem
32852799   Curated Info

2

Torregrossa MM, et al. (2018) Phosphoproteomic analysis of cocaine memory extinction and reconsolidation in the nucleus accumbens. Psychopharmacology (Berl)
30411139   Curated Info

3

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

4

Gil C, et al. (2011) Protein kinase CK2 associates to lipid rafts and its pharmacological inhibition enhances neurotransmitter release. FEBS Lett 585, 414-20
21187092   Curated Info

5

Dubois T, et al. (2002) Identification of syntaxin-1A sites of phosphorylation by casein kinase I and casein kinase II. Eur J Biochem 269, 909-14
11846792   Curated Info

6

Foletti DL, Lin R, Finley MA, Scheller RH (2000) Phosphorylated syntaxin 1 is localized to discrete domains along a subset of axons. J Neurosci 20, 4535-44
10844023   Curated Info