Tyr337

Site Information
SKTKEGKyRVDFHNF SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 451246

In vivo Characterization
Methods used to characterize site in vivo:	microscopy-colocalization with upstream kinase ( 2 ) , mutation of modification site ( 1 , 2 , 4 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:	293 (epithelial) [ROMK (human)] ( 4 ) , 293 (epithelial) [Src (human)] ( 4 ) , 293 (epithelial) ( 2 ) , HEK293T (epithelial) ( 1 )

Downstream Regulation
Effects of modification on ROMK:	activity, inhibited ( 1 ) , intracellular localization ( 2 , 4 )

References
1	Yue P, et al. (2009) Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels. Proc Natl Acad Sci U S A 106, 15061-6 19706464 Curated Info
2	Sterling H, Lin DH, Wei Y, Wang WH (2003) Tetanus toxin abolishes exocytosis of ROMK1 induced by inhibition of protein tyrosine kinase. Am J Physiol Renal Physiol 284, F510-7 12556363 Curated Info
3	Lin DH, et al. (2002) K depletion increases protein tyrosine kinase-mediated phosphorylation of ROMK. Am J Physiol Renal Physiol 283, F671-7 12217858 Curated Info
4	Sterling H, et al. (2002) Inhibition of protein-tyrosine phosphatase stimulates the dynamin-dependent endocytosis of ROMK1. J Biol Chem 277, 4317-23 11719519 Curated Info