Thr388
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Home > Phosphorylation Site Page: > Thr388  -  SMAD3 (human)

Site Information
GAEYRRQtVTSTPCW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1243500

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
PD98059 ( 1 ) , TGF-beta ( 1 )

Downstream Regulation
Effects of modification on SMAD3:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
transcription, induced ( 1 ) , transcription, inhibited ( 2 )
Induce interaction with:
CDK8 (human) ( 1 ) , SMAD4 (human) ( 1 ) , TUBB2B (human) ( 2 )

References 

1

Qu X, et al. (2014) Regulation of renal fibrosis by Smad3 thr388 phosphorylation. Am J Pathol 184, 944-52
24485922   Curated Info

2

Gong K, et al. (2011) cGMP inhibits TGF-beta signaling by sequestering Smad3 with cytosolic beta2-tubulin in pulmonary artery smooth muscle cells. Mol Endocrinol 25, 1794-803
21868450   Curated Info