Ser206
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Home > Phosphorylation Site Page: > Ser206  -  SMAD1 (human)

Site Information
SSStYPHsPTSSDPG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451175

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
cervical cancer ( 1 ) , cervical adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , COS (fibroblast) ( 3 ) , HaCaT (keratinocyte) ( 1 , 2 ) , HeLa S3 (cervical) ( 1 ) , MEF (fibroblast) ( 1 ) , R-1B/L17 (epithelial) ( 3 )

Upstream Regulation
Regulatory protein:
FOXO4 (human) ( 1 ) , SMAD1 (mouse) ( 1 ) , SMAD4 (human) ( 1 ) , SMURF1 (mouse) ( 1 )
Putative in vivo kinases:
CDK7 (human) ( 1 ) , CDK8 (human) ( 1 ) , CDK9 (human) ( 1 )
Kinases, in vitro:
CDK8 (human) ( 1 ) , CDK9 (human) ( 1 ) , ERK2 (human) ( 1 , 2 , 3 )
Treatments:
alvocidib ( 1 ) , amanitin ( 1 ) , BMP2 ( 1 , 2 ) , EGF ( 2 , 3 ) , FGF1 ( 2 ) , HGF ( 3 ) , hypertonic_buffer ( 2 ) , insulin ( 2 ) , MG132 ( 1 ) , SB203580 ( 1 ) , serum_starvation ( 3 ) , SP600125 ( 1 ) , TGF-beta ( 1 , 2 ) , U0126 ( 1 ) , UV ( 1 , 2 ) , wortmannin ( 3 )

Downstream Regulation
Effects of modification on SMAD1:
intracellular localization ( 2 , 3 ) , molecular association, regulation ( 1 , 2 ) , protein degradation ( 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
transcription, altered ( 1 )
Induce interaction with:
YAP1 (human) ( 1 )

References 

1

Alarcón C, et al. (2009) Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 139, 757-69
19914168   Curated Info

2

Sapkota G, et al. (2007) Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell 25, 441-54
17289590   Curated Info

3

Kretzschmar M, Doody J, Massagué J (1997) Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 389, 618-22
9335504   Curated Info