Ser187
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Home > Phosphorylation Site Page: > Ser187  -  SMAD1 (human)

Site Information
NSHPFPHsPNSSYPN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451173

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 2 , 4 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
cervical cancer ( 2 ) , cervical adenocarcinoma ( 2 ) , pancreatic cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , COS (fibroblast) ( 4 ) , HaCaT (keratinocyte) ( 2 , 3 ) , HeLa S3 (cervical) ( 2 ) , MEF (fibroblast) ( 2 ) , PC-1 (pancreatic) ( 1 ) , PC1.0 (pancreatic) ( 1 ) , R-1B/L17 (epithelial) ( 4 )

Upstream Regulation
Kinases, in vitro:
CDK8 (human) ( 2 ) , CDK9 (human) ( 2 ) , ERK2 (human) ( 2 , 4 )

Downstream Regulation
Effects of modification on SMAD1:
intracellular localization ( 4 )

Disease / Diagnostics Relevance
Relevant diseases:
pancreatic ductal adenocarcinoma ( 1 )

References 

1

Tan X, et al. (2016) Phosphoproteome Analysis of Invasion and Metastasis-Related Factors in Pancreatic Cancer Cells. PLoS One 11, e0152280
27014871   Curated Info

2

Alarcón C, et al. (2009) Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 139, 757-69
19914168   Curated Info

3

Sapkota G, et al. (2007) Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell 25, 441-54
17289590   Curated Info

4

Kretzschmar M, Doody J, Massagué J (1997) Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 389, 618-22
9335504   Curated Info