Ser21
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Home > Phosphorylation Site Page: > Ser21  -  Kv3.4 (human)

Site Information
KsGNKPPsKTCLKEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451078

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
oocyte ( 2 ) , oocyte [CPEB (mouse)] ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 2 )
Kinases, in vitro:
PKCA (rat) ( 1 ) , PKCB (human) ( 1 ) , PKCG (human) ( 1 )

Downstream Regulation
Effects of modification on Kv3.4:
activity, inhibited ( 2 ) , protein conformation ( 2 ) , receptor inactivation, altered ( 1 )

References 

1

Beck EJ, Sorensen RG, Slater SJ, Covarrubias M (1998) Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action. J Gen Physiol 112, 71-84
9649584   Curated Info

2

Covarrubias M, Wei A, Salkoff L, Vyas TB (1994) Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate. Neuron 13, 1403-12
7993631   Curated Info