Ser71
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Home > Phosphorylation Site Page: > Ser71  -  CRY1 (mouse)

Site Information
ANLRKLNsRLFVIRG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11952908

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 1 ) , AD293 (epithelial) ( 3 ) , fibroblast ( 1 ) , HEK293T (epithelial) ( 2 ) , liver ( 1 ) , MEF (fibroblast) ( 3 ) , muscle ( 1 )

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (human) ( 3 )
Treatments:
acadesine ( 3 )

Downstream Regulation
Effects of modification on CRY1:
molecular association, regulation ( 3 ) , protein degradation ( 1 , 3 )
Induce interaction with:
FBXL3 (human) ( 3 )
Inhibit interaction with:
PER2 (human) ( 3 )

References 

1

Vaughan M, et al. (2019) Phosphorylation of CRY1 Serine 71 Alters Voluntary Activity but Not Circadian Rhythms In Vivo. J Biol Rhythms 34, 401-409
31258021   Curated Info

2

Tong X, et al. (2015) CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1. PLoS One 10, e0139725
26431207   Curated Info

3

Lamia KA, et al. (2009) AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326, 437-40
19833968   Curated Info