Ser588
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Home > Phosphorylation Site Page: > Ser588  -  CRY1 (mouse)

Site Information
LSSGkRPsQEEDAQs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11952906

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 4 , 5 , 6 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
bone cancer ( 3 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 4 ) , AD293 (epithelial) ( 6 ) , E.coli (bacterial) ( 1 ) , HeLa (cervical) ( 5 ) , liver ( 2 ) , MEF (fibroblast) [CRY1 (mouse), homozygous knockout] ( 3 ) , U2OS (bone cell) ( 3 )

Upstream Regulation
Regulatory protein:
DNAPK (mouse) ( 3 )
Treatments:
insulin ( 4 ) , vanadate ( 3 )

Downstream Regulation
Effects of modification on CRY1:
protein stabilization ( 3 )

References 

1

Parico GCG, et al. (2020) The human CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1. Proc Natl Acad Sci U S A
33106415   Curated Info

2

Robles MS, Humphrey SJ, Mann M (2017) Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology. Cell Metab 25, 118-127
27818261   Curated Info

3

Gao P, et al. (2013) Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length. J Biol Chem 288, 35277-86
24158435   Curated Info

4

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

5

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

6

Lamia KA, et al. (2009) AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326, 437-40
19833968   Curated Info