Thr358
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Home > Phosphorylation Site Page: > Thr358  -  Myc (mouse)

Site Information
EENDKRRtHNVLERQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450960

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 2 ) , HEK293T (epithelial) ( 2 ) , keratinocyte-skin ( 1 )

Upstream Regulation
Regulatory protein:
PAK2 (human) ( 2 )
Putative in vivo kinases:
PAK2 (mouse) ( 2 )
Kinases, in vitro:
PAK2 (mouse) ( 2 )
Treatments:
osmotic_stress ( 2 )

Downstream Regulation
Effects of modification on Myc:
activity, inhibited ( 1 , 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , cell cycle regulation ( 2 ) , cell growth, altered ( 2 ) , transcription, altered ( 1 ) , transcription, inhibited ( 2 )

References 

1

Berta MA, Baker CM, Cottle DL, Watt FM (2010) Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation. EMBO Mol Med 2, 16-25
20043278   Curated Info

2

Huang Z, Traugh JA, Bishop JM (2004) Negative control of the Myc protein by the stress-responsive kinase Pak2. Mol Cell Biol 24, 1582-94
14749374   Curated Info