Ser37
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Home > Phosphorylation Site Page: > Ser37  -  p53 (mouse)

Site Information
PPEDILPsPHCMDDL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869726220

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 1 ) , modification-specific antibody ( 3 ) , mutation of modification site ( 2 , 3 , 4 , 5 ) , phospho-antibody ( 3 ) , phosphopeptide mapping ( 5 ) , western blotting ( 2 , 3 , 4 )
Disease tissue studied:
cancer, squamous cell carcinoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
ionizing_radiation ( 3 ) , UV ( 3 )

Downstream Regulation
Effects of modification on p53:
phosphorylation ( 2 )

References 

1

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

2

Warnock LJ, Raines SA, Mee TR, Milner J (2005) Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins. FEBS J 272, 1669-75
15794754   Curated Info

3

Knights CD, Liu Y, Appella E, Kulesz-Martin M (2003) Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification. J Biol Chem 278, 52890-900
14555661   Curated Info

4

Hao M, et al. (1996) Mutation of phosphoserine 389 affects p53 function in vivo. J Biol Chem 271, 29380-5
8910602   Curated Info

5

Wang Y, Eckhart W (1992) Phosphorylation sites in the amino-terminal region of mouse p53. Proc Natl Acad Sci U S A 89, 4231-5
1584757   Curated Info