Ser846
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Home > Phosphorylation Site Page: > Ser846  -  GluR6 (rat)

Site Information
VGEFLYKsKKNAQLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11496000

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 3 ) , 'neuron, hippocampal' ( 3 ) , 293 (epithelial) ( 2 ) , COS (fibroblast) ( 3 ) , neuron-'brain, hippocampus' ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 3 )
Treatments:
chelerythrine ( 3 ) , kainic_acid ( 3 )

Downstream Regulation
Effects of modification on GluR6:
molecular association, regulation ( 2 ) , receptor recycling, inhibited ( 1 )
Effects of modification on biological processes:
exocytosis, inhibited ( 1 )
Induce interaction with:
14-3-3 theta (human) ( 2 )

References 

1

Evans AJ, et al. (2017) Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity. Cell Rep 19, 2613-2626
28636947   Curated Info

2

Sun C, et al. (2013) Modulation of GluK2a Subunit-containing Kainate Receptors by 14-3-3 Proteins. J Biol Chem 288, 24676-90
23861400   Curated Info

3

Konopacki FA, et al. (2011) Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis. Proc Natl Acad Sci U S A 108, 19772-7
22089239   Curated Info