Tyr218
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Home > Phosphorylation Site Page: > Tyr218  -  CTLA-4 (mouse)

Site Information
CEKQFQPyFIPIN__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450898

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:
Jurkat (T lymphocyte) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Fyn (mouse) ( 1 ) , Lck (mouse) ( 1 )
Kinases, in vitro:
Lck (mouse) ( 1 )
Treatments:
vanadate ( 1 )

Downstream Regulation
Effects of modification on CTLA-4:
molecular association, regulation ( 1 )
Induce interaction with:
SHP-2 (mouse) ( 1 )

References 

1

Chuang E, et al. (1999) Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J Immunol 162, 1270-7
9973379   Curated Info

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