Tyr251

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Home > Phosphorylation Site Page: > Tyr251 - CASP9 (human)

Site Information
LQFPGAVyGTDGCPV SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1147026600

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 1 )

Upstream Regulation
Kinases, in vitro:	Src (human) ( 1 )

Downstream Regulation
Effects of modification on CASP9:	enzymatic activity, induced ( 1 )
Effects of modification on biological processes:	apoptosis, induced ( 1 )

References
1	Fu Y, et al. (2018) Dasatinib reduces 5-Fu-triggered apoptosis in colon carcinoma by directly modulating Src-dependent caspase-9 phosphorylation. Cell Death Discov 4, 61 29844931 Curated Info

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