Ser601
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Home > Phosphorylation Site Page: > Ser601  -  GPIbA (human)

Site Information
WLLFLRGsLPTFRsS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11333102

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , CHO (fibroblast) ( 2 ) , platelet-blood ( 2 )

Downstream Regulation
Effects of modification on GPIbA:
molecular association, regulation ( 2 )
Induce interaction with:
14-3-3 zeta (human) ( 2 ) , VWF (human) ( 2 )
Inhibit interaction with:
FLNA (human) ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Yuan Y, et al. (2009) Identification of a novel 14-3-3zeta binding site within the cytoplasmic domain of platelet glycoprotein Ibalpha that plays a key role in regulating the von Willebrand factor binding function of glycoprotein Ib-IX. Circ Res 105, 1177-85
19875727   Curated Info