Ser352
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Home > Phosphorylation Site Page: > Ser352  -  CNR2 (human)

Site Information
kITPWPDsRDLDLSD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450818

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mass spectrometry ( 2 ) , phospho-antibody ( 3 )
Relevant cell line - cell type - tissue:
CHO (fibroblast) [EphB1 (human), transfection] ( 3 ) , Jurkat (T lymphocyte) ( 2 )

Upstream Regulation
Putative upstream phosphatases:
PPP2CA (human) ( 3 )
Treatments:
CP-55940 ( 3 ) , SR_144528 ( 3 )

Downstream Regulation
Effects of modification on CNR2:
receptor desensitization, altered ( 3 )

References 

1

Chen X, et al. (2014) Involvement of β-arrestin-2 and Clathrin in Agonist-Mediated Internalization of the Human Cannabinoid CB2 Receptor. Curr Mol Pharmacol 7, 67-80
25023974   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

3

Bouaboula M, Dussossoy D, Casellas P (1999) Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses. J Biol Chem 274, 20397-405
10400664   Curated Info