Lys123
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Home > Acetylation Site Page: > Lys123  -  SOD1 (mouse)

Site Information
RTMVVHEkQDDLGkG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11317132

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mass spectrometry ( 2 , 3 , 4 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 1 ) , 'brain, hippocampus, CA1 region' ( 1 ) , 'brain, hippocampus, dentate gyrus' ( 1 ) , 'neuron, cerebellar granule' ( 1 ) , 'neuron, olfactory' ( 1 ) , 293 (epithelial) ( 1 ) , astrocyte ( 1 ) , dendritic cell ( 1 ) , glial-brain ( 1 ) , liver ( 2 , 3 ) , neuron-'brain, hippocampus' ( 1 ) , retina ( 1 ) , spinal cord ( 1 )

Upstream Regulation
Treatments:
gut microbiota ( 3 ) , nicotinamide ( 1 ) , trichostatin_A ( 1 )

Downstream Regulation
Effects of modification on SOD1:
intracellular localization ( 1 )

References 

1

Kaliszewski M, et al. (2016) SOD1 Lysine 123 Acetylation in the Adult Central Nervous System. Front Cell Neurosci 10, 287
28066183   Curated Info

2

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info

3

Simon GM, Cheng J, Gordon JI (2012) Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice. Proc Natl Acad Sci U S A 109, 11133-8
22733758   Curated Info

4

Yang L, et al. (2011) The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching. J Proteome Res 10, 4134-49
21728379   Curated Info

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